kratom potentiators

What Are The Best Ways To Potentiate The Kratom Effects?

What helps in potentiating the kratom? You must be wondering about it, but you have natural things sitting right in your kitchen.

There are many methods for potentiating kratom and boosting its efficacy. The combination of certain herbs and foods can result in a synergistic effect which results in enhancement of herbal remedies example Kratom. This method results in potentiation, leading to the improvement of potency and strength of kratom with smaller dosages and with profound effects.

Compounds which help in potentiating the Kratom

The kratom powder is derived from the Mitragyna Speciosa tree. Its potency is increased by some common foods which we intake daily. According to the user’s experience, the best foods for potentiating kratom include:

Grapefruit Juice: It is an optimal potentiator and is used commonly in routine life by the kratom users. The users recommend the combination of kratom with grapefruit juice so that it can be easily swallowed and the bitter taste is alleviated.

The users use this method for prolonged motivation to use kratom and get help in reducing the bitterness, but the actual benefit with its combination is that the benefits endured longer with this consumption method. Grapefruit peels also contribute to accomplishing the same results.

The grapefruit juice enhances the kratom effects, but the chemical of grapefruit juice influences the digestive enzymes linking with the metabolism of kratom alkaloids, doubling the strength for the treatment of pain or anxiety.

Turmeric: turmeric is a type of ordinary spice grown in India. It is the perfect spice which surpasses the other foods which help in intensifying the kratom potency. The turmeric produces an encompassing intensification of various physical effects produced by kratom along with the extension of results.

The users claim turmeric as an active boost for kratom effects.

Cayenne Pepper: it is an especial hot pepper which helps in detoxing and cleansing the body. It aids in increasing the kratom’s potency and effects. Users prefer mixing the cayenne pepper with dry kratom powder. The pepper has an intense spiciness so use it in meager amounts.

The cayenne pepper is a powerful compound which helps in producing saliva for digestion, aids in weight loss and helps in relieving the joint pain with the use of kratom.

The combination of black pepper with the kratom helps in increasing the kratom’s potency along with it lowers the tolerance level.

Watercress: it is an ultra-hydrating lettuce which significantly potentiates the kratom effects. It is an effective natural food with a powerful mineral that potentiates the effects of kratom.

Guide for potentiating the Kratom tea

Add regular herbal teas with kratom, as opposed to brewing kratom alone as a tea. It is a good choice for integrating the herbal tea in your supplement routine. The common herbal teas include passion flower and chamomile. These herbal teas enhance the soothing effects, especially of the Red Vein kratom strains.

If you are choosing the green or white kratom strain for more energizing effects, Add yerba mate tea to it.

Supplements that help in potentiating the Kratom effects

These supplements include:

Valerian root: the root helps in a peaceful sleep and enhances the relaxing effects of various kratom strains.

Caffeine: the coffee has an enough amount of caffeine which helps in reducing the lethargy effects, that is a mild side effect of different kratom strains. The combination of caffeine with kratom increases the alertness, energy, and focus.

Cat’s claw: this herb has alkaloids which are like kratom. If you take cat’s claw along with kratom, it will intensify the effects and potency of any kratom strain. This woody vine is found in Central and South America. It is scientifically referred to as “Uncaria Tomentosa,” contains the alkaloids which synergize the kratom alkaloids for increasing the duration of kratom’s effects.

Timing for the use of potentiators with Kratom

Bear in mind that kratom stacks are ineffective until you ingest it at the same time or take it immediately after kratom ingestion. It is recommended that you should consume the potentiating herb or food around 45 minutes before ingesting kratom to accomplish the optimal effects. Expect longer effectual periods for kratom intake.

How do the potentiators results in high Kratom?

According to the science, how do the common foods potentiate the kratom? The foods which have the potentiating component works by regulating the metabolism, mainly focusing on the cytochrome P-450 enzyme. The alkaloids in kratom undergo breakdown along with the removal process due to the help of cytochrome P-450 enzyme within the system. Foods which result in reducing the enzyme function helps in extending the kratom effects.

Drugs which potentiate the effects of Kratom

The drugs which potentiate the effects of kratom leads to the inhibition of kratom’s metabolism in the digestive system, especially in the liver. However, these drugs result in dangerous interaction with liver’s microsomal enzyme system specifically CYP3A4 and CYP2D6.

These drugs lead to tolerance and adverse effects with a high dosage of kratom or more than the recommended amount. These drugs include:

Tianeptine: it enhances the euphoric consequences by the consumption of kratom.

Diphenhydramine: it enhances the sedative effects of kratom.

Acetaminophen: it increases the pain-relieving and analgesic effects of kratom.

Agmatine: it is also termed as Guanidine, which aids in improving the ability of kratom to treat the opiate addiction.

Magnesium: Magnesium is a popular supplement with potentiating effects. It serves in reducing the tolerance if used for long-term, allowing you to use less amount of kratom with time.

Magnesium helps in relieving constipation but will worsen diarrhea. This drug results in adverse effects on patients who are in self-weaning process with the use of opiates.

Phenibut: It is a substance which is available as a supplement and a prescription drug. It helps in treating multiple ailments example, anxiety, PTSD (post-traumatic stress disorder), and insomnia. It helps in potentiating the effects of kratom for relaxation.

Cimetidine or Tagamet: It amplifies the kratom effects. It is an over-the-counter drug which helps in treating the gastric ailments along with the heartburn. The recommended dosage of this medication is effective to potentiate the kratom effects.

Note: Do not take more than one herb or supplement with your kratom experience. Users claim that one additive is more than enough for achieving the maximum results with kratom, it is not necessary to add more than one additive as it will not potentiate the benefits.


The combination of potentiators with kratom strain results in a long duration of effects. It allows the user to get through with adequate doses feeling more stimulated, relaxed and peaceful. With potentiators, the effects of kratom are more powerful and heightened.

jennifer kurtz
Jennifer Kurtz is a founder of and studied medicine at the New Jersey School of Medicine (Rutgers). She is passionate about developing her knowledge of Cannabis, Nootropics, Kratom, and nutritional supplements. In addition to attending medical webinars and conferences, she loves to write research-based articles for magazines, healthcare professionals, and medical agencies.

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